Keyed by early dominating defense, Duke stormed out to a 20-2 start and never gave Virginia a chance as the Devils returned home with a convincing 82-63 victory at Cameron Indoor Stadium.
J.J. Redick turned in another outstanding performance with 40 points, including 8-of-10 shooting from three point range to keep the lead at a comfortable margin all night.
It was Sean Dockery's defensive presence in the first five minutes of the game that set the tone for this blowout, though.
Dockery hounded Virginia point guard Sean Singletary into three early turnovers to enable Duke to go on its big run at the outset of the game.
Dockery only put in three points on the offensive end, but his five steals and three assists were huge factors in the easy triumph.
The Cavaliers entered the game allowing only 40 percent field goal shooting against ACC competition, but Duke sliced through them most of the night and ended with a 55 percent clip to go along with a sparkling 56 percent mark from three point range.
Redick had 11 of Duke's first 15 points, including a trio of three pointers in the game's first six and a half minutes.
Singletary's runner in the lane just under the 11 minute mark finally gave Virginia its second field goal of the game, but the hole was already too deep.
The margin tightened to nine on a J.R. Reynolds three point basket late in the first half, but Shelden Williams canned a mid range jumper on the half's final play to push the lead back to 11 at 35-24.
Williams started the second half in identical fashion, knocking home a 15 footer less than 10 seconds into the action to get Duke off on the right foot again.
After the lead briefly went back to 12, Duke blew the doors off with a 24-7 spurt that stretched the lead to a game high 61-32 at the 12:44 mark.
The 29 point margin was reached when freshman Martynas Pocius entered the lineup and quickly cut through the lane for a driving layup.
In his second game of action since being injured against Maryland, DeMarcus Nelson played 20 minutes and contributed four points, including two on a very impressive move into the lane on the right side for a twisting layup.
Duke was deadly on offense when the Blue Devils took care of the ball. If there is a black mark on this game for Duke however, it is the 17 turnovers they committed.
Greg Paulus and Redick each gave it away four times, while Williams and Josh McRoberts turned it over three times apiece.
McRoberts had his second straight active game. The freshman put in nine points and got two steals in his 20 minutes of action, though he only pulled down four rebounds as Duke was outrebounded 31-28 by an undersized Virginia team.
Williams had another quiet double-double, thanks in large part to five offensive rebounds that helped him reach 10 for the game. He scored 17 points, including a three pointer late in the game to delight the Cameron Crazies. The Landlord wasn't far from his second triple-double performance as he tallied a dominating eight blocks.
Duke improves to 19-1 with the win and stays unbeaten in the ACC while winning their second straight game in impressive fashion since last Saturday's loss at Georgetown.